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CAS RN: 54-05-7 | 产品编码: C3730
Chloroquine
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| 产品编码 | C3730 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__8H__2__6ClN__3 = 319.88 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 54-05-7 |
| Reaxys-RN | 482809 |
| PubChem物质ID | 468591247 |
| Merck Index (14) | 2163 |
| MDL编号 | MFCD00024009 |
技术规格
| Appearance | White to Light yellow powder to lump |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 89.0 to 93.0 °C |
| Specific rotation | -1.0 to +1.0 deg (C=1, methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 91 °C |
| 最大吸收波长 | 228(H2O) nm |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | VB2360000 |
运输信息
| HS编码* | 2933.49-000 |
应用
Exosome research
References
- Interfering with endolysosomal trafficking enhances release of bioactive exosomes
应用
Chloroquine: A Derivative of 4-Aminoquinoline with Autophagy Inhibitory, Antimalarial and Anticancer Activities
Chloroquine is a derivative of 4-aminoquinoline, which is an inhibitor of autophagy and has antimalarial and anticancer activities.1-3) In addition, chloroquine has been also reported to exert anti-corona viral activity, including anti-SARS-CoV-2, in vitro.4-6) The mechanism of action of chloroquine is not completely understood. But, some studies have demonstrated that chloroquine is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. In addition, while chloroquine can inhibit certain enzymes, its effect is believed to result, at least in part from its interaction with DNA. (The product is for research purpose only.)
References
- 1) Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
- 2) Antimalarial Agents: Chloroquine, Hydroxychloroquine, and Quinacrine (a review)
- 3) Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells
- 4) In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine
- 5) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- 6) Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
- 7) Chloroquine phosphate (a review on the physical properties, synthesis, metabolites, and methods of analysis)
- 8) Sensitive and rapid liquid chromatography/tandem mass spectrometric assay for the quantification of chloroquine in dog plasma
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