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CAS RN: 41621-49-2 | 产品编码: C3545
Ciclopirox Olamine
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| 产品编码 | C3545 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__2H__1__7NO__2·C__2H__7NO = 268.36 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 41621-49-2 |
| 相关CAS RN | 29342-05-0 |
| Reaxys-RN | 6494273 |
| PubChem物质ID | 468591150 |
| Merck Index (14) | 2266 |
| MDL编号 | MFCD00078997 |
技术规格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
物性（参考值）
| 熔点 | 143 °C |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | UU7785500 |
运输信息
| HS编码* | 2933.79-000 |
应用
Mitophagy research
References
- Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
应用
Ciclopirox Olamine: An Antifungal Agent with Additional Antibacterial, Anti-Inflammatory and Antitumor Activities
Ciclopirox olamine is a synthetic, broad-spectrum antifungal agent with additional antibacterial, anti-inflammatory and also recently antitumor activities. In vitro studies have suggested that ciclopirox olamine acts by chelation of trivalent cations, such as Fe3+ and Al3+, resulting in the inhibition of the metal-dependent enzymes that are responsible for the cellular metabolism, organization of cell wall structure and other crucial cell functions.1,2) In addition, ciclopirox olamine exerts its anti-inflammatory activity by scavenging the reactive oxygen species (ROS) released from inflammatory cells.2) In 2000s, some studies have reported that ciclopirox olamine could be repositioned as a new antitumor agent.3-5) (The product is for research purpose only.)
References
- 1)Ciclopirox: an overview
- 2)Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent (a review)
- 3)Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells
- 4)The antitumor activity of the fungicide ciclopirox
- 5)The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy (a review)
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