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CAS RN: 59729-32-7 | 产品编码: C2370
Citalopram Hydrobromide
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| 产品编码 | C2370 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__2__1FN__2O·HBr = 405.31 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 59729-32-7 |
| 相关CAS RN | 59729-33-8 |
| Reaxys-RN | 5368282 |
| PubChem物质ID | 125307911 |
| Merck Index (14) | 2318 |
| MDL编号 | MFCD02101306 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 183 °C(dec.) |
GHS
相关法规
| RTECS# | NP6406750 |
运输信息
| HS编码* | 2932.99-000 |
应用
Citalopram Hydrobromide: A Selective Serotonin Reuptake Inhibitor (SSRI)
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). It is a racemic bicyclic phthalane derivative consisting of a 1:1 mixture of the R(-)- and S(+)[E0958] -enantiomers. The mechanism of action of citalopram HBr as an antidepressant is presumed to be linked to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT) [S0370]. In vitro and in vivo studies suggest that citalopram a highly SSRI with minimal effects on norepinephrine (NA) [A0906] and dopamine (DA) [A0305] neural reuptake. In additon, citalopram has no antagonistic activity towards DA, NA, 5-HT, histamine [H0146, H0147], GABA [A0282], acetylcholine [A0084, chloride], and morphine receptors. Although, the inhibition primarily due to the active S(+)-enantiomer, it is reported that the R(-)-enantiomer counteracts the activity of the S(+)[E0958] -enantiomer. (The product is for research purpose only.)
References
- Citalopram-pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity
- Citalopram (a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness)
- Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram
- Escitalopram versus citalopram: the surprising role of the R-enantiomer
- Determination of citalopram and escitalopram together with their active main metabolites desmethyl(es-)citalopram in human serum by column-switching high performance liquid chromatography (HPLC) and spectrophotometric detection
- Analytical procedures for the determination of the selective serotonin reuptake inhibitor antidepressant citalopram and its metabolites (a review)
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