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CAS RN: 56-25-7 | 产品编码: C0019
Cantharidin
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| 产品编码 | C0019 |
| 纯度/分析方法 | >98.0%(GC) |
| 分子式/分子量 | C__1__0H__1__2O__4 = 196.20 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 应避免的情况 | 光 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 56-25-7 |
| Reaxys-RN | 85302 |
| PubChem物质ID | 125308680 |
| Merck Index (14) | 1752 |
| MDL编号 | MFCD00134968 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 215.0 to 219.0 °C |
物性（参考值）
| 熔点 | 217 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | RN8575000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | I |
| HS编码* | 2932.99-000 |
应用
Cantharidin: A Strong Inhibitor of Protein Phosphatases Types 1 (PP1) and 2A (PP2A)
Cantharidin is a toxic terpenoid compound in the blood of blister beetles. Cantharidin acts as a strong inhibitor of protein phosphatases types 1 (PP1) and 2A (PP2A) which are enzymes that remove a phosphate group from the phosphorylated amino acid residue of its substrate protein. Cantharidin has been used to reat warts and molluscum as a traditional medicine. Recently, several studies have demonstrated that cantharidin has anticancer, antibiotic, antivirus activities and immune-regulated functions. (The product is for research purpose only.)
References
- Cantharidin-binding protein: Identification as protein phosphatase 2A
- Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A
- Molecular modes of action of cantharidin in tumor cells
- Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways
- The effects of cantharidin and cantharidin derivates on tumour cells (a review)
- Exploiting protein phosphatase inhibitors based on cantharidin analogues for cancer drug discovery (a review)
参考文献
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