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CAS RN: 199875-69-9 | 产品编码: A3446
N-Arachidonoyl Dopamine
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纯度/分析方法: >98.0%(HPLC)
别名：
- N-花生四烯酰多巴胺
- (5Z,8Z,11Z,14Z)-N-[2-(3,4-二羟基苯基)乙基]-5,8,11,14-二十烷四烯酰胺
- (5Z,8Z,11Z,14Z)-N-[2-(3,4-二羟基苯基)乙基]二十烷-5,8,11,14-四烯酰胺
- NADA
- (5Z,8Z,11Z,14Z)-N -[2-(3,4-Dihydroxyphenyl)ethyl]-5,8,11,14-eicosatetraenamide
- (5Z,8Z,11Z,14Z)-N-(3,4-Dihydroxyphenethyl)icosa-5,8,11,14-tetraenamide
产品文档：
| 产品编码 | A3446 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__8H__4__1NO__3 = 439.64 |
| 外观与形状（20°C） | 液体 |
| 储存温度 | 冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,空气,加热 |
| CAS RN | 199875-69-9 |
| Reaxys-RN | 7779367 |
| MDL编号 | MFCD03412031 |
技术规格
| Appearance | Colorless to Yellow clear liquid |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 闪点 | 341 °C |
GHS
相关法规
运输信息
| HS编码* | 2924.19-000 |
应用
N-Arachidonoyldopamine: An Endogenous Cannabinoid
N-Arachidonoyldopamine (NADA) is was first synthesized as a pharmacological tool to study the endogenous cannabinoid system (ECS).1) Later NADA and other N-acyldopamines were identified as endogenous cannabinoids in the mammalian nervous tissue.2,3) It has been reported that NADA acts as an agonist of the cannabinoid 1 (CB1) receptors.1-3) It is selective for CB1 over CB2 receptors. Furthermore, NADA also acts as an agonist of the transient receptor potential vanilloid type 1 (TRPV1) ion channel, also known as the capsaicin receptor.2,3) For your reference, the endogenous cannabinoid system (ECS) modulates neuronal and immune cell function, both of which play key roles in pain, therapeutics targeting this system hold promise as novel analgesics.3) (The product is for research purpose only.)
References
- 1) N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
- 2) An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
- 3) N-arachidonoyl dopamine: a novel endocannabinoid and endovanilloid with widespread physiological and pharmacological activities (a review)
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