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CAS RN: 7770-78-7 | 产品编码: A3117
(-)-Arctigenin
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| 产品编码 | A3117 |
| 纯度/分析方法 | >95.0%(GC) |
| 分子式/分子量 | C__2__1H__2__4O__6 = 372.42 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 10MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 7770-78-7 |
| Reaxys-RN | 4206071 |
| PubChem物质ID | 354335432 |
| MDL编号 | MFCD00870597 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 95.0 % |
| Melting point | 98.0 to 102.0 °C |
| Specific rotation [a]20/D | -40.0 to -44.0 deg(C=1, methanol) |
物性（参考值）
| 熔点 | 100 °C |
| 比旋光度 [α]D | -42° (C=1,MeOH) |
| 最大吸收波长 | 280(EtOH) nm |
GHS
相关法规
| RTECS# | LY9247000 |
运输信息
| HS编码* | 2932.20-000 |
应用
Arctigenin: A Lignin with Wide Pharmacological Actions
Arctigenin and its glycoside, arctiin [A3118], are lignans found in many plants of Arctium lappa L. (AL, family Asteraceae)1). Arctigenin reportedly has wide pharmacological actions, such as antitumor2,3), anti-inflammatory4-6), and antiviral7,8), and anti-Alzheimer9) actions. (The product is for research purpose only.)
References
- 1)Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS
- 2)Identification of Arctigenin as an Antitumor Agent Having the Ability to Eliminate the Tolerance of Cancer Cells to Nutrient Starvation
- 3)Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity
- 4)In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway
- 5)Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway
- 6)Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages
- 7)(-)-Arctigenin as a Lead Structure for Inhibitors of Human Immunodeficiency Virus Type-1 Integrase
- 8)Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus
- 9)Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance
参考文献
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