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CAS RN: 1451042-18-4 | 产品编码: A2897
N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide
![N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide No-Image](/medias/A2897.jpg?context=bWFzdGVyfHJvb3R8NDkxMDZ8aW1hZ2UvanBlZ3xhRGN4TDJneU1pODRPVEU1TmpnMU1UTTJOREUwTDBFeU9EazNMbXB3Wnd8NTFhYmEyNTk5NmJhOGIzZTM2ZDM5YjZjYjFhMDc4ZDU0MDk2ZTNmNzBmN2Q3YWRiZjZjMjBlYTYwNDkxNjljYw)
产品编码 | A2897 |
纯度/分析方法 | >95.0%(HPLC) |
分子式/分子量 | C__2__1H__1__9N__5OS = 389.48 |
外观与形状(20°C) | 固体 |
储存温度 | 冷冻 (<0°C) |
储存在惰性气体下 | 存放于惰性气体之中 |
应避免的情况 | 空气,加热 |
CAS RN | 1451042-18-4 |
PubChem物质ID | 354333140 |
技术规格
Appearance | White to Yellow to Orange powder to crystal |
Purity(HPLC) | min. 95.0 area% |
Elemental analysis(Nitrogen) | 17.00 to 19.00 % |
NMR | confirm to structure |
物性(参考值)
熔点 | 236 °C |
GHS
象形图 |
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信号词 | Warning |
危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
HS编码* | 2934.99-000 |
应用
A Histone Deacetylase 3 (HDAC3) Selective Inhibitor
Suzuki et al. have reported that this compound (T247) shows potent histone deacetylase 3 (HDAC3) inhibitions, whereas it does not strongly inhibit other isozymes. T247 also induces a dose-dependent selective NF-kB acetylation in human colon cancer HCT116 cells, indicating selective inhibition of HDAC3 in the cells. In addition, T247 induced growth inhibition of cancer cells, and activated HIV gene expression in latent HIV-infected cells. These findings indicate that T247 alone or a combination agent may be useful in the treatment of cancer or HIV infection. (The product is for research purpose only.)
References
- Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly
- Triazole ring-containing amides, their preparation, and their use for pharmaceuticals and HDAC3 inhibitors
- N. Miyata, T. Suzuki, Y. Kasuya, JP 2013-170164 A
参考文献
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