Maximum quantity allowed is 999
请选择数量
CAS RN: 344423-98-9 | 产品编码: A2476
Atorvastatin Calcium Salt Trihydrate
×
![]()
×
| 产品编码 | A2476 |
| 纯度/分析方法 | >98.0%(HPLC)(N) |
| 分子式/分子量 | C__6__6H__6__8CaF__2N__4O__1__0·3H__2O = 1,209.41 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 344423-98-9 |
| 相关CAS RN | 134523-03-8&134523-00-5 |
| PubChem物质ID | 135727313 |
| Merck Index (14) | 864 |
| MDL编号 | MFCD09752074 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | -7.0 to -10.0 deg(C=1、DMSO)(calcd.on anh.substance) |
| Water | 3.5 to 5.5 % |
物性（参考值）
| 比旋光度 [α]D | -8° (C=1,DMSO) |
| 水溶性 | 不溶 |
| 溶解性（不溶于） | 乙醇 |
GHS
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Atorvastatin Calcium Salt: A Most Potent HMG-CoA Reductase Inhibitor
Enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase catalyzes the rate-limiting step in cholesterol biosynthesis. Statins inhibit the action of HMG-CoA reductase resulting in the reduction of low-density-lipoprotein (LDL) and total cholesterol levels. Especially in statins, atorvastatin calcium salt is a most potent statin because it has a long half-life and metabolites which also play a role as an HMG-CoA reductase inhibitor. Atorvastatin metabolized by cytochrome P450 3A4 (CYP3A4). In addition, we have a synthetic intermediate (atorvastatin acetonide tert-butyl ester [B3690]) for atorvastatin calcium salt. (The product is for research purpose only.)
References
- Structural mechanism for statin inhibition of HMG-CoA reductase
- The discovery and development of atorvastatin, a potent novel hypolipidemic agent (a review)
- HPLC methods for the determination of simvastatin and atorvastatin
- Atorvastatin calcium (a review on preparation, physical characteristics, methods of analysis, stability, metabolism, and pharmacokinetics of atorvastatin calcium)
参考文献
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
化学品安全说明书(SDS)
请选择语言。
如需更多帮助，请联系我 们。
技术规格
CoA及其他文档
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
示例 CoA
可下载CoA示例。注：该示例不一定是最新批次的CoA。
目前没有该产品的 CoA 示例。
分析图谱
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
很抱歉，您搜索的分析图谱无法提供。