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CAS RN: 59703-84-3 | Product Number: P1774
Piperacillin Sodium Salt
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Purity: >98.0%(N)
Synonyms:
Product Documents:
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| 1G |
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| Product Number | P1774 |
| Purity / Analysis Method | >98.0%(N) |
| Molecular Formula / Molecular Weight | C__2__3H__2__6N__5NaO__7S = 539.54 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 59703-84-3 |
| Related CAS RN | 61477-96-1 |
| Reaxys Registry Number | 5373920 |
| PubChem Substance ID | 87560271 |
| Merck Index (14) | 7463 |
| MDL Number | MFCD00056867 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | +170 to +190 deg(C=0.8, H2O)(calcd.on anh.substance) |
| Water | max. 5.0 % |
Properties (reference)
| Melting Point | 185 °C(dec.) |
| Specific Rotation | 180° (C=0.8,H2O) |
GHS
Related Laws:
| RTECS# | XI0180000 |
Transport Information:
| H.S.code* | 2941.10-000 |
Application
Piperacillin Sodium: A Broad Spectrum Penicillin with an Increased Activity against Pseudomonas Aeruginosa
iperacillin sodium, a number of so-called broad spectrum penicillins, is chemically synthesized from 6-APA [A0800]. Piperacillin have an increased activity against many Gram-negative bacteria, especially Pseudomonas aeruginosa, Klebsiella pneumonia and Serratia marcescens. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Piperacillin is often used in combination with tazobactam [T3732] which is a β-lactamase inhibitor to increase the antibiotic spectrum of it. Piperacillin–tazobactam has a broad spectrum of antibacterial activity that includes Gram-positive and -negative aerobic and anaerobic bacteria.
References
- In vitro activity of piperacillin, a new semisynthetic penicillin with an unusually broad spectrum of activity
- In vitro and in vivo activity of piperacillin, a new broad-spectrum semisynthetic penicillin
- Azlocillin, mezlocillin, and piperacillin: new broad-spectrum penicillins (a review)
- Piperacillin/Tazobactam: A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential (a review)
- Permeations of antimicrobial agents through Pseudomonas aeruginosa biofilms. A simple method
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