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SIRT2 Inhibitor
Sirtuin 2 (SIRT2) is a histone deacetylase (HDAC) and plays an important role in cell cycle progression. AGK-2 (1) inhibits mammalian SIRT2 with IC50 = 3.5 μM.1), at the same time, 1 has less activity (at up to 40 μM) against SIRT1 and SIRT3. 1 also rescues dopamine neurons from α-synuclein–mediated toxicity in a Drosophila model of Parkinson’s disease.
References
- 1)Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease
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