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CAS RN: 80214-83-1 | Product Number: R0164
Roxithromycin
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Purity: >95.0%(HPLC)
Synonyms:
- Erythromycin 9-[O-(2-Methoxyethoxy)methyloxime]
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
₩120,300
|
2 | 9 | Contact Us | |
| 25G |
₩325,600
|
19 | 1 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | R0164 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__1H__7__6N__2O__1__5 = 837.06 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 80214-83-1 |
| Reaxys Registry Number | 5900029 |
| PubChem Substance ID | 253661176 |
| Merck Index (14) | 8276 |
| MDL Number | MFCD00214389 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 3.10 to 3.60 % |
| Specific rotation [a]20/D | -93.0 to -96.0 deg(C=1, Acetone)(calcd.on anh.substance) |
| Water | max. 3.0 % |
Properties (reference)
| Melting Point | 120 °C |
| Specific Rotation | -95° (C=1,Acetone) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | KF4990000 |
Transport Information:
| H.S.code* | 2941.90-000 |
Application
Roxithromycin: An Acid-Stable and Enteric Absorbent Semi-Synthetic Macrolide Antibiotic
Macrolide antibiotics are classified by the size of the macrocyclic lactone ring of aglycone as 14-, 15- or 16-membered ring macrolides. Macrolides are characterized by similar chemical structures, mechanisms of action and resistance, but vary in the different pharmacokinetic parameters, and spectrum of activity. Roxithromycin (abbrev: RXM) is chemically synthesized from erythromycin [E0751] to create a more acid-stable antimicrobial and prevents the degradation of the erythromycin base to the hemiketal intermediate. RXM has an in vitro antibacterial profile similar to that of erythromycin. RXM has a pharmacokinetic profile that is characterized by excellent enteric absorption within macrolide antibiotics achieving high concentrations in most tissues and body fluids. In addition, RXM immunomodulatory activities have reported.
References
- A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy
- The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin (a review)
- Roxithromycin: review of its antimicrobial activity
- Analysis of macrolide antibiotics (a review)
- Determination of erythromycin, clarithromycin, roxithromycin, and azithromycin in plasma by high-performance liquidchromatography with amperometric detection
- Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin
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