CAS RN: 284461-73-0 | Product Number: O0599

Sorafenib

Purity: >98.0%(T)(HPLC)

Synonyms:

BAY 43-9006
4-[4-[3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido]phenoxy]-N-methylpicolinamide

Product Documents:

Size	Unit Price	Same Day	2-3 Business Days
500MG	₩486,600	8	28

* Please contact our distributor of SEJIN CI Co., Ltd. if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email: sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.

General Information plus

Product Number	O0599
Purity / Analysis Method	>98.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C__2__1H__1__6ClF__3N__4O__3 = 464.83
Physical State (20 deg.C)	Solid
Storage Temperature	Refrigerated (0-10°C)
Store Under Inert Gas	Store under inert gas
Condition to Avoid	Air Sensitive,Heat Sensitive
Packaging and Container	500MG-Glass Bottle with Plastic Insert (View image)
CAS RN	284461-73-0
Reaxys Registry Number	9666200
MDL Number	MFCD06411450

Specifications & Properties plus

Specifications

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Volumetric Analysis)	min. 98.0 %
Melting point	203.0 to 207.0 °C
NMR	confirm to structure

Properties (reference)

Melting Point

205 °C

Safety & Regulations plus

GHS

Pictogram
Signal Word	Danger
Hazard Statements	H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H372 : Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up.

Related Laws:

RTECS#

US4588870

Transport Information:

H.S.code*

2933.39-000

*This code is applied to the products when TCI exports from Japan and not for import in your country.

Applications plus

Application

Sorafenib: An Inhibitor of Multiple Protein Kinases

The Ras/Raf/MEK/ERK signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. Sorafenib (BAY 43-9006) inhibits intracellular Raf kinases (C-Raf, B-Raf and mutant B-Raf) and cell surface receptor tyrosine kinases (c-KIT, FLT- 3, RET, VEGFR-1, VEGFR- 2, VEGFR- 3, and PDGFR).^1-4) Several of these kinases are thought to be involved in tumor cell signaling, angiogenesis and apoptosis. In fact, sorafenib decreases tumor cell proliferation and angiogenesis in vitro. There are reports, that sorafenib also inhibits LRRK2 (Leucine-rich repeat kinase 2) –G2019S that is a promising therapeutic target for the treatment of Parkinson's disease.⁵⁾ (The product is for research purpose only.)