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CAS RN: 50-91-9 | Product Number: D2235
2'-Deoxy-5-fluorouridine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-(2-Deoxy-β-D-ribofuranosyl)-5-fluorouracil
- 5-Fluoro-2'-deoxy-β-uridine
- Floxuridine
- FUDR
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
₩103,600
|
23 | ≥60 | Contact Us | |
| 500MG |
₩316,400
|
17 | 33 | Contact Us | |
| 1G |
₩560,600
|
1 | ≥80 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | D2235 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__1FN__2O__5 = 246.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image), 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 50-91-9 |
| Reaxys Registry Number | 90221 |
| PubChem Substance ID | 87568673 |
| SDBS (AIST Spectral DB) | 19323 |
| Merck Index (14) | 4112 |
| MDL Number | MFCD00006530 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 148.0 to 152.0 °C |
Properties (reference)
| Melting Point | 150 °C |
| Specific Rotation | 38° (C=1,H2O) |
| Solubility in water | Soluble |
| Solubility (soluble in) | Alcohol, Acetone |
| Solubility (insoluble in) | Ether, Benzene, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | YU7525000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2934.99-000 |
Application
Floxuridine: An Antitumor Antimetabolite with Inhibition of Thymidylate Synthase
Floxuridine (FUDR), an antitumor antimetabolite, is a prodrug of 5-fluorouracil (5-FU) [F0151]. Floxuridine is rapidly catabolized to 5-FU in vivo. Similarly to 5-FU, floxuridine inhibits thymidilate synthetase (TS) which is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). dTMP forms thymidine, a nucleic acid in deoxyribonucleic acid (DNA). Therefore, the primary effect of floxuridine is to interfere with the synthesis of DNA. (The product is for research purpose only.)
References
- Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine
- Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors (a review)
- Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer (a review)
PubMed Literature
Articles/Brochures
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