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CAS RN: 133052-90-1 | Product Number: B5781
Bisindolylmaleimide I
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Purity: >97.0%(HPLC)
Synonyms:
- GF 109203X
- 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 5MG |
₩297,900
|
Contact Us | 7 |
| 25MG |
₩1,050,800
|
24 | 7 |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | B5781 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__2__4N__4O__2 = 412.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 133052-90-1 |
| Reaxys Registry Number | 7952743 |
| PubChem Substance ID | 468590702 |
| MDL Number | MFCD00236428 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Melting point | 268.0 to 272.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 270 °C |
| Maximum Absorption Wavelength | 466(EtOH) nm |
GHS
Related Laws:
| RTECS# | UX9590000 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Bisindolylmaleimide I: A Potent, Selective and Competitive Inhibitor of Protein Kinase C (PKC)
Protein kinase C (PKC) isoforms, a family of serine/threonine protein kinases, are thought to mediate numerous signal transduction processes including the control of cell growth, differentiation and homeostasis. Bisindolylmaleimide I (GF 109203X) a potent, selective and competitive inhibitor of PKC isoforms.1-3) Bisindolylmaleimide I (GF 109203X) also inhibits LRRK2 (Leucine-rich repeat kinase 2) –G2019S that is a promising therapeutic target for the treatment of Parkinson's disease.4) (The product is for research purpose only.)
References
- 1) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
- 2) The protein kinase C inhibitors Ro318220 and GF109203X are equally potent inhibitors of MAPKAP kinase-1β (Rsk-2) and p70S6 kinase
- 3) The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
- 4) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
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