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CAS RN: 429-41-4 | Product Number: T1338
Tetrabutylammonium Fluoride (ca. 1mol/L in Tetrahydrofuran)
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Purity:
Priority Assessment Chemical Substance
Synonyms:
- TBAF (ca. 1mol/L in Tetrahydrofuran)
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 25ML |
¥2,700
|
≥40 | 34 | 30 | |
| 100ML |
¥6,400
|
≥100 | It can be shipped from Saitama warehouse on the same day* | It can be shipped in about 2 weeks after ordering | |
| 500ML |
¥19,000
|
11 | ≥40 | ≥40 |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
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* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T1338 |
| Molecular Formula / Molecular Weight | C__1__6H__3__6FN = 261.47 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 429-41-4 |
| Reaxys Registry Number | 3570522 |
| PubChem Substance ID | 87577107 |
| Merck Index (14) | 9187 |
| MDL Number | MFCD00011747 |
Specifications
| Appearance | Colorless to Red to Green clear liquid |
| Concentration(Nonaqueous Titration) | 1.0 to 1.1 mol/L |
| Water | max. 10.0 % |
| TBHF-HF(neutralization titration) | max. 5.0 % |
| Bromide | max. 1.0 % |
Properties (reference)
| Flash point | -17 °C |
| Specific Gravity (20/20) | 0.92 |
| Solubility in water | Completely miscible |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H314 : Causes severe skin burns and eye damage. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H351 : Suspected of causing cancer. H335 : May cause respiratory irritation. H225 : Highly flammable liquid and vapor. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P240 : Ground/bond container and receiving equipment. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233 : Keep container tightly closed. P201 : Obtain special instructions before use. P243 : Take precautionary measures against static discharge. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P242 : Use only non-sparking tools. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
Related Laws:
| Chemical Substance Law (ENCS) | Priority Assessment Chemical Substance |
| ISHL |
Organic Solvents Class 2 |
| PRTR Law (New Specific Chemical) | Class 1 Designated Chemical Substances |
| Fire Defense Law | Group-4-1-II |
Transport Information:
| UN Number | UN2924 |
| Class | 3 / 8 |
| Packing Group | II |
Application
TCI Practical Example: Selective TBDPS-Deprotection of a Compound Protected by Acetonide and TBDPS Groups
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Used Chemicals
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- 5-O-tert-Butyldiphenylsilyl-2,3-O-isopropylidene-D-ribono-1,4-lactone
- TBAF (ca. 1mol/L in Tetrahydrofuran) [T1338]
- THF
-
Procedure
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To a mixture of 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-D-ribono-1,4-lactone (100 mg, 0.234 mmol) in THF (100 mL) was cooled with an ice/water bath. TBAF (ca. 1 mol/L in THF, 0.3652 mL, 0.352 mmol) was added dropwise to the mixture and stirred at the same temperature for 2 h. sat. NH4Cl aq. (10 mL) and ethyl acetate (25 mL) were added to the reaction mixture and the two layers were separated. The organic layer was washed with water (10 mL), sat. NaCl aq. (10 mL), dried over Na2SO4 and concentrated under reduced pressure. The residue was triturated in hexane (5 mL) to give 2,3-O-isopropylidene-D-ribonic γ-lactone (0.0389 g, 88% yield) as a white solid.
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Experimenter’s Comments
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The reaction mixture was monitored by TLC (dichloromethane:ethyl acetate = 9:1, Rf = 0.5, stained by KMnO4 solution containing K2CO3 and NaOH).
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Analytical Data
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1H NMR (400 MHz, CDCl3); δ 4.82(d, 1H, J = 5.6 Hz), 4.76 (d, 1H, J = 5.6 Hz), 4.61 (t, 1H, J = 2.0 Hz), 4.00 – 3.95 (1H, m), 3.83 - 3.78 (1H, m), 1.88 (1H, t, J = 5.2 Hz), 1.47 (3H, s), 1.37 (3H, s).
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Other Reference
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- Novel Deprotection of SEM Ethers: A Very Mild and Selective Method Using Magnesium Bromide
Application
Generation of Benzyne and Reaction with Furan
Reference
- A New and Efficient Hypervalent Iodine-Benzyne Precursor, (Phenyl)[o-(trimethylsilyl)phenyl]iodonium Triflate: Generation, Trapping Reaction, and Nature of Benzyne
Application
Synthesis of β,β-Difluorohomoallylic Alcohols
Typical Procedure:
Under an argon atmosphere, TBAF (1.0 M in THF, 1.5 mL, 1.5 mmol) is added into a suspension of flame-dried MS4Å (1.0 g) in THF (4.0 mL) and the mixture is stirred at room temperature for 2.0 h. Then the mixture is cooled at －20 °C and a solution of ethyl 4,4-difluoro-3-(triethylsilyl)but-3-enoate (265 mg, 1.0 mmol) and benzaldehyde (204 µL, 2.0 mmol) is added to the mixture over 1.0 h at －20 °C. After stirring the mixture for
1 h at the same temperature, the whole is poured into aqueous 10% HCl, extracted with Et2O and the organic layer is dried with anhydrous MgSO4. After evaporation of the solvent, the residue is purified by column chromatography (SiO2, EtOAc : hexane) to give the desired product.
Under an argon atmosphere, TBAF (1.0 M in THF, 1.5 mL, 1.5 mmol) is added into a suspension of flame-dried MS4Å (1.0 g) in THF (4.0 mL) and the mixture is stirred at room temperature for 2.0 h. Then the mixture is cooled at －20 °C and a solution of ethyl 4,4-difluoro-3-(triethylsilyl)but-3-enoate (265 mg, 1.0 mmol) and benzaldehyde (204 µL, 2.0 mmol) is added to the mixture over 1.0 h at －20 °C. After stirring the mixture for
1 h at the same temperature, the whole is poured into aqueous 10% HCl, extracted with Et2O and the organic layer is dried with anhydrous MgSO4. After evaporation of the solvent, the residue is purified by column chromatography (SiO2, EtOAc : hexane) to give the desired product.
References
- New approach to synthesize β,β-difluorohomoallylic alcohols
PubMed Literature
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Other Documents
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| Product # | T1125 |
| CAS RN | 429-41-4 |
| Purity / Analysis Method: |
Tetrabutylammonium Fluoride (70-75% in Water)
| Product # | T1339 |
| CAS RN | 429-41-4 |
| Purity / Analysis Method: |