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Published TCIMAIL newest issue No.197
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CAS RN: 58066-85-6 | Product Number: M2445
Miltefosine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Hexadecyl 2-(Trimethylammonio)ethyl Phosphate
- Phosphoric Acid Hexadecyl 2-(Trimethylammonio)ethyl Ester
- Hexadecyl Phosphorylcholine
- HePC
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
24,00 €
|
2 | 9 |
|
| 1G |
150,00 €
|
1 | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2445 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__4__6NO__4P = 407.58 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 58066-85-6 |
| Reaxys Registry Number | 3690495 |
| PubChem Substance ID | 253660169 |
| Merck Index (14) | 6198 |
| MDL Number | MFCD00133396 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Water | max. 7.0 % |
Properties (reference)
| Melting Point | 216 °C(dec.) |
| Maximum Absorption Wavelength | 283(EtOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| RTECS# | KH2890000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2923900090 |
Application
Miltefosine: an Antitumor and Anti-Leishmanial Agent
Miltefosine was originally developed as an antitumor agent, but recently it has been successfully used for the treatment of leishmaniasis caused by protozoan parasites of the genus Leishmania.
References
- Hexadecylphosphocholine: a new and selective antitumor drug
- Advances in leishmaniasis
- Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes
- Possible mechanism of miltefosine-mediated death of Leishmania donovani
- In vitro and in vivo interactions between miltefosine and other antileishmanial drugs
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