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CAS RN: 10405-02-4 | Product Number: T3305
Trospium Chloride
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Purity: >98.0%(HPLC)(N)
Synonyms:
Product Documents:
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| 200MG |
$111.00
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6 | 19 | Contact Us | |
| 1G |
$368.00
|
7 | 8 | Contact Us |
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| Product Number | T3305 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__5H__3__0ClNO__3 = 427.97 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 10405-02-4 |
| Related CAS RN | 47608-32-2 |
| Reaxys Registry Number | 5899018 |
| PubChem Substance ID | 253661222 |
| Merck Index (14) | 9786 |
| MDL Number | MFCD00865254 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
Properties (reference)
| Melting Point | 262 °C(dec.) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | WH1424000 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Trospium chloride: A Muscarinic Receptor Antagonist
Trospium chloride, a quaternary ammonium compound, is a muscarinic receptor antagonist. It binds specifically and with high affinity to muscarinic M1, M2 and M3 receptor subtypes, but not nicotinic receptors. It blocks the contractile effect of acetylcholine on the smooth musculature of urinary bladder through binding linkage to the muscarinic receptors. Therefore, it is used for the treatment of bladder overactivity. Trospium chloride is hydrophilic and does not cross the normal blood-brain barrier in significant amounts, so that it has minimal central anticholinergic activity. Trospium chloride undergoes negligible metabolized by the cytochrome P 450 system, and therefore has a low potential for drug interactions. (The product is for research purpose only.)
References
- Trospium chloride in the management of overactive bladder (a review)
- Muscarinic receptor antagonists for overactive bladder (a review)
- Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system
- Inhibitory effects of trospium chloride on cytochrome P450 enzymes in human liver microsomes
- Determination of the quaternary ammonium compound trospium in human plasma by LC-MS/MS: Application to a pharmacokinetic study
- New stability-indicating RP-UFLC method for determination of trospium chloride in tablet dosage form
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