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CAS RN: 115956-12-2 | Product Number: D5820
Dolasetron
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Purity: >98.0%(HPLC)
Synonyms:
- 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate
- 1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 10MG |
¥265.00
|
Contact Us | Contact Us | 16 |
| 50MG |
¥1,250.00
|
Contact Us | Contact Us | 20 |
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| Product Number | D5820 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__0N__2O__3 = 324.38 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 115956-12-2 |
| Reaxys Registry Number | 8441335 |
| PubChem Substance ID | 468591584 |
| Merck Index (14) | 3411 |
| MDL Number | MFCD00865542 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 234.0 to 238.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 236 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 505 mg/l 25 °C |
GHS
Related Laws:
| RTECS# | NL6014644 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Dolasetron: A Selective Serotonin Subtype 3 (5-HT3) Receptor Antagonist
Dolasetron is the free base of dolasetron mesylate [D5481] which is a selective serotonin subtype 3 (5-HT3) receptor antagonist. It is rapidly converted in vivo to its active major metabolite, hydrodolasetron, which appears to be largely responsible for its pharmacological activity. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, selective 5-HT3 receptor antagonists, dolasetron, granisetron [G0401], ondansetron [O0407] and tropisetron [T2743] are used for the prevention of chemotherapy-induced nausea and vomiting, but they have been reported to be associated with QTc prolongation. (The product is for research purpose only.)
References
- Dolasetron: a review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery (a review)
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Specifications
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