Make sure to sign up for an account today for exclusive coupons and free shipping on orders over $75!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 107007-99-8 | Product Number: G0401
Granisetron Hydrochloride
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide Hydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 200MG |
$64.00
|
1 | 1 | 3 |
|
| 1G |
$217.00
|
2 | 1 | 29 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | G0401 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__4N__4O·HCl = 348.88 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 107007-99-8 |
| Related CAS RN | 109889-09-0 |
| Reaxys Registry Number | 3640184 |
| PubChem Substance ID | 172089139 |
| Merck Index (14) | 4536 |
| MDL Number | MFCD01747034 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 292 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NK7882200 |
Transport Information:
| HS Number | 2933.99.7500 |
Application
Granisetron Hydrochloride: A Potent and Highly Selective 5-Hydroxytryptamine 3 (5-HT3) Receptor Antagonist
Granisetron hydrochloride is a potent and highly selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist that has little or no affinity for other serotonin receptors, including 5-HT1; 5-HT1A; 5-HT1B/C; 5-HT2; for α1-, α2- or β-adrenergic receptors; for dopamine-D2; or for histamine-H1; benzodiazepine; picrotoxin or opioid receptors. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, granisetron is used for the prevention of chemotherapy-induced nausea and vomiting. (The product is for research purpose only.)
References
- Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron)
- 5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives
- [3H]-BRL 43694 (granisetron), a specific ligand for 5-HT3 binding sites in rat brain cortical membranes
- Structural features of the ligand-binding domain of the serotonin 5HT3 receptor
- Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: Are they all the same?(a review)
- Direct plasma liquid chromatographic-tandem mass spectrometric analysis of granisetron and its 7-hydroxy metabolite utilizing internal surface reversed-phase guard columns and automated column switching devices
- Development and application of a validated stability-indicating HPLC method for simultaneous determination of granisetron hydrochloride, benzyl alcohol and their main degradation products in parenteral dosage forms
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.