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CAS RN: 163451-81-8 | Product Number: T3287

Teriflunomide


Purity: >98.0%(GC)
Synonyms:
  • N-[4-(Trifluoromethyl)phenyl]-2-cyano-3-hydroxycrotonamide
  • (Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Product Documents:
100MG
A$256.00
3   31  
1G
A$1,170.00
32   2  
* Please contact our distributor of Chem-Supply if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination.
* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email:  sales@chemsupply.com.au)

Product Number T3287
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__1__2H__9F__3N__2O__2 = 270.21 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (-20°C)
Condition to Avoid Heat Sensitive
Packaging and Container 100MG-Glass Bottle with Plastic Insert (View image),  1G-Glass Bottle with Plastic Insert (View image)
CAS RN 163451-81-8
Reaxys Registry Number 6655982
PubChem Substance ID 253661385
Merck Index (14) 9165
MDL Number

MFCD00910058

Specifications
Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Melting point 227.0 to 231.0 °C
Properties (reference)
Melting Point 229 °C
Maximum Absorption Wavelength 203(MeOH) nm
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
Transport Information:
H.S.code* 2926.90-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Teriflunomide: An Immunomodulatory Compound

Teriflunomide (A77 1726), the active metabolite of leflunomide [L0250], is an immunomodulatory compound. Teriflunomide has two activites: inhibition of pyrimidine nucleotide synthesis and interference with tyrosine phosphorylation. More specifically, it inhibits the enzymic activity of dihydroorotate dehydrogenase (DHO-DHase) which catalyzes the fourth step in the biosynthesis of pyrimidine, and tyrosine kinases which transfer a phosphate group from ATP to a protein in a cell. Teriflunomide reduces the proliferation of T and B immune cells that are active in multiple sclerosis (MS). For your reference, [C3217] is a synthetic intermediate. (The product is for research purpose only.)

References


PubMed Literature


TCIMAIL
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