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CAS RN: 108612-45-9 | Product Number: M2756
Mizolastine
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
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| Product Number | M2756 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__5FN__6O = 432.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 108612-45-9 |
| Reaxys Registry Number | 7259331 |
| PubChem Substance ID | 253661171 |
| Merck Index (14) | 6221 |
| MDL Number | MFCD23140913 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 222.0 to 226.0 °C |
Properties (reference)
| Melting Point | 224 °C |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
| RTECS# | UW7481284 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
ヒスタミンH1-受容体アンタゴニスト，ミゾラスチン
Mizolastine is a histamine H1-receptor antagonist with no anticholinergic, antiadrenergic, or antiserotonin activity. It is used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. (The product is for research purpose only.)
References
- In vivo and in vitro interaction of the novel selective histamine H1 receptor antagonist mizolastine with H1 receptors in the rodent
- Anti-anaphylactic activity of the novel selective histamine H1 receptor antagonist mizolastine in the rodent
- Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat
- Comparison of pharmacokinetics and metabolism of desloratadine [D3787], fexofenadine [F0698], levocetirizine [L0264] and mizolastine in humans (a review)
- Determination of mizolastine, a new antihistaminic drug, in human plasma by liquid-liquid extraction, solid-phase extraction and column-switching techniques in combination with high-performance liquid chromatography
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