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CAS RN: 443-48-1 | Product Number: M0924
2-Methyl-5-nitroimidazole-1-ethanol
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Purity: >99.0%(GC)(T)
Synonyms:
- Metronidazole
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 25G |
A$196.00
|
≥40 | ≥100 |
| 500G |
A$1,352.00
|
12 | ≥40 |
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* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
| Product Number | M0924 |
| Purity / Analysis Method | >99.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__6H__9N__3O__3 = 171.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 443-48-1 |
| Reaxys Registry Number | 611683 |
| PubChem Substance ID | 87572910 |
| SDBS (AIST Spectral DB) | 18702 |
| Merck Index (14) | 6157 |
| MDL Number | MFCD00009750 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 99.0 % |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 159.0 to 163.0 °C |
| Solubility in hot Methanol | almost transparency |
Properties (reference)
| Melting Point | 161 °C |
| Solubility in water | Slightly soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | NI5600000 |
Transport Information:
| H.S.code* | 2933.29-000 |
Application
Metronidazole: A Nitroimidazole Antibiotic against Protozoans and Anaerobic Bacteria
2-Methyl-5-nitroimidazole-1-ethanol (metronidazole) is a synthetic nitroimidazole antibiotic such as azomycin [N0891] and dimetridazole [D1564]. Metronidazole has a limited spectrum of activity that encompasses various protozoans and most Gram-negative and Gram-positive anaerobic bacteria. Metronidazole is bactericidal through toxic metabolites (hydroxyl radicals) which cause bacterial DNA strand breakage. Metronidazole is active against Helicobacter pylori, however resistance to metronidazole is high. Thus, the combination of lansoprazole [L0233] or omeprazole [O0359] (as a proton pump inhibitor), amoxicillin [A2099] and metronidazole is used for the eradication of Helicobacter pylori.
References
- Metronidazole in anaerobic infections: A review of its activity, pharmacokinetics and therapeutic use (a review)
- Metronidazole: a therapeutic review and update
- Why metronidazole is active against both bacteria and parasites
- Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials
- Basis for the management of drug-resistant Helicobacter pylori infection (a review)
- Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase
- Mutation discovery in bacterial genomes: metronidazole resistance in Helicobacter pylori
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