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CAS RN: 68767-14-6 | Product Number: L0244
Loxoprofen
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Purity: >97.0%(T)(HPLC)
Synonyms:
- 2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionic Acid
Product Documents:
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| 5G |
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18 | ≥100 | Contact Us |
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| Product Number | L0244 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__8O__3 = 246.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 68767-14-6 |
| Reaxys Registry Number | 2860055 |
| PubChem Substance ID | 354333699 |
| Merck Index (14) | 5589 |
| MDL Number | MFCD00864331 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
Properties (reference)
| Melting Point | 111 °C |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2916.39-000 |
Application
Loxoprofen: A Prodrug of Non-Steroidal Anti-Inflammatory Drug and a Non-Selective Cyclooxygenase Inhibitor
Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen[I0415], ketoprofen[K0038] and naproxen[M1021] among others. loxoprofen is a prodrug that is rapidly converted to its active trans-alcohol metabolite (loxoprofen-SRS) following oral administration. Loxoprofen is a non-selective cyclooxygenase inhibitor. It works by reducing the synthesis of prostaglandins from arachidonic acid. Loxoprofen has more potent analgesic activity than that of ketoprofen or naproxen. (The product is for research purpose only.)
References
- Species differences in metabolism of sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate (loxoprofen sodium), a new antiinflammatory agent
- Structural determination of rat urinary metabolites of sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate (loxoprofen sodium), a new antiinflammatory agent
- Inhibition of prostaglandin production in the inflammatory tissue by loxoprofen-Na, an anti-inflammatory prodrug
- Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites
- Simultaneous analysis of several non-steroidal anti-inflammatory drugs in human urine by high-performance liquid chromatography with normal solid-phase extraction
- Rapid and simultaneous determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS with solid-phase extraction
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