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CAS RN: 19685-09-7 | Product Number: H1463
10-Hydroxycamptothecin
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 1G |
A$529.00
|
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| Product Number | H1463 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__6N__2O__5 = 364.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 19685-09-7 |
| Reaxys Registry Number | 3019077 |
| PubChem Substance ID | 354335739 |
| MDL Number | MFCD02093100 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
Properties (reference)
| Melting Point | 267 °C |
| Specific Rotation | 35.3° (C=0.11,CH2Cl2:MeOH=4:1) |
| Maximum Absorption Wavelength | 382 nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | UQ0491700 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2939.79-000 |
Application
10-Hydroxycamptothecin: An Inhibitor of Topoisomerase I with Antitumor Activity
10-hydroxycamptothecin (10-HCPT) is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. 10-HCPT, a member of the camptothecin family, interferes with DNA synthesis by inhibiting the enzyme topoisomerase-I, and has a broad spectrum of antitumor activity and less toxicity as a camptothecins.1,2) However, 10-HCPT is insoluble in both water and physiological acceptable organic solvents and tends to change into its carboxylate form, which shows minimal antitumor activity and several unpredictable side effects.3,4) Therefore, appropriate drug delivery systems (DDS) for 10-HPCT have been developed to improve the stability of its lactone form.5,6) 10-HCPT is also an important precursor for the synthesis of the clinical useful anticancer agents, such as irinotecan [I0714]. (The product is for research purpose only.)
References
- 1)Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents
- 2)Synthesis and Preliminary Anticancer Evaluation of 10-Hydroxycamptothecin Analogs
- 3)Preparation, characterization and biodistribution of the lactone form of 10-hydroxycamptothecin (HCPT)-loaded bovine serum albumin (BSA) nanoparticles
- 4)Simultaneous determination of the carboxylate and lactone forms of 10-hydroxycamptothecin in human serum by restricted-access media high-performance liquid chromatography
- 5)10-Hydroxycamptothecin loaded nanoparticles: Preparation and antitumor activity in mice
- 6)Efficient tumor targeting of hydroxycamptothecin loaded PEGylated niosomes modified with transferrin
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