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CAS RN: 3056-17-5 | Product Number: D3580
2',3'-Didehydro-3'-deoxythymidine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- d4T
- 2',3'-Anhydrothymidine
- 1-(2,3-Dideoxy-β-D-glycero-2-pentenofuranosyl)thymine
- Stavudine
- Sanilvudine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 1G |
A$142.00
|
2 | 7 |
| 5G |
A$451.00
|
16 | 1 |
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* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | D3580 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__2N__2O__4 = 224.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 3056-17-5 |
| Reaxys Registry Number | 618327 |
| PubChem Substance ID | 87559878 |
| SDBS (AIST Spectral DB) | 52178 |
| MDL Number | MFCD00132921 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -44.0 to -48.0 deg(C=0.69, H2O) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 166 °C(dec.) |
| Specific Rotation | -46° (C=0.69,H2O) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H373 : May cause damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | XP2075000 |
Transport Information:
| H.S.code* | 2940.00-000 |
Application
Stavudine: A Nucleoside Reverse Transcriptase Inhibitor
Stavudine is a nucleoside reverse transcriptase inhibitor that active against HIV1. Stavudine is a synthetic nucleoside analogue of the naturally occurring nucleoside thymidine. Intracellularly, stavudine is converted by cellular enzymes to the active metabolite, stavudine-5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, thymidine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)
References
- Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus
- Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T) (a review)
- Comparison of metabolism and in vitro antiviral activity of stavudine versus other 2',3'-dideoxynucleoside analogues
Application
Synthesis and Anti-HIV-1 Activities of Novel Podophyllotoxin Derivatives Containing Stavudine
References
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Articles/Brochures
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