Maximum quantity allowed is 999
Please select the quantity
CAS RN: 152120-55-3 | Product Number: B3605
N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine
- N,N'-Di-Cbz-1H-pyrazole-1-carboxamidine
- 1-[N,N'-Bis(carbobenzoxy)amidino]pyrazole
- 1-[N,N'-(Di-Cbz)amidino]pyrazole
- N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboximidamide
- N,N'-Di-Cbz-1H-pyrazole-1-carboximidamide
View All
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 1G |
A$106.00
|
17 | 4 |
| 5G |
A$363.00
|
4 | 5 |
* Please contact our distributor of Chem-Supply
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination.
* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
| Product Number | B3605 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__8N__4O__4 = 378.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 152120-55-3 |
| Reaxys Registry Number | 6160514 |
| PubChem Substance ID | 125307472 |
| MDL Number | MFCD02683516 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 91.0 to 95.0 °C |
Properties (reference)
| Melting Point | 93 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.19-000 |
Application
TCI Practical Example: Di-Cbz Guanidinylation of Amine Using the Pyrazole Derivative
-
Used Chemicals
-
Procedure
-
A solution of 4-bromophenethylamine (200 mg, 1.00 mmol) and 1-[N,N'-(di-Cbz)amidino]pyrazole (416 mg, 1.10 mmol) in THF (1.7 mL) was stirred at ambient temperature for one day. The reaction mixture was concentrated and the residue was purified by column chromatography (ethyl acetate:hexane = 0:100 – 10:90 on silica gel) to give the guanidinylated compound 1 as a pale yellow oil (435 mg, 85% yield.).
-
Experimenter’s Comments
-
The reaction mixture was monitored by TLC (ethyl acetate:hexane = 1:3, Rf = 0.45).
-
Analytical Data
-
Guanidinylated Compound 1
1H NMR (270 MHz, DMSO-d6); δ 11.58 (s, 1H), 8.44 (t, J = 6.4 Hz, 1H), 7.49-7.31 (m, 12H), 7.18 (d, J = 8.1 Hz, 2H), 5.20 (s, 2H), 5.04 (s, 2H), 3.55 (brq, J = 6.4 Hz, 2H), 2.80 (t, J = 6.4 Hz, 2H)
-
Lead Reference
-
- Urethane protected derivatives of 1-guanylpyrazole for the mild and efficient preparation of guanidines
Application
Synthesis of monosubstituted guanidines
Typical procedure (synthesis of bis-Cbz guanidine derivative): To the 1-guanylpyrazole derivative (B3605, 378 mg) was added aniline (102 mg) followed by dry THF (0.4 mL) and the resulting mixture was stirred for 22 h at room temperature. The reaction mixture was purified by column chromatography to give the bis-Cbz guanidine derivative as an oil (379 mg, 94 %).
References
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.