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CAS RN: 39831-55-5 | Product Number: A2281
Amikacin Sulfate
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Purity: >98.0%(HPLC)
Synonyms:
- Amikacin Disulfate
- O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine Sulfate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
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|---|---|---|---|---|---|
| 5G |
A$119.00
|
34 | 15 | It can be shipped in about 2 weeks after ordering | |
| 25G |
A$329.00
|
1 | 12 | It can be shipped in about 2 weeks after ordering |
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| Product Number | A2281 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__4__3N__5O__1__3·2H__2SO__4 = 781.75 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| CAS RN | 39831-55-5 |
| Reaxys Registry Number | 6172633 |
| PubChem Substance ID | 468590111 |
| Merck Index (14) | 405 |
| MDL Number | MFCD00167475 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Specific rotation | +76.0 to +84.0 deg(C=1, water)(calcd.on anh.substance) |
| Water | max. 13.0 % |
Properties (reference)
| Melting Point | 230 °C(dec.) |
GHS
Related Laws:
| RTECS# | WK1961200 |
Transport Information:
| H.S.code* | 2941.90-000 |
Application
Amikacin sulfate: A Polycationic Bactericidal Aminoglycoside
Amikacin sulfate is a polycationic, semisynthetic, bactericidal aminoglycoside. Amikacin was synthesized by acylation with the L-(-)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the deoxystreptamine moiety of kanamycin [K0047]. Amikacin is very active against most Gram-negative bacteria including gentamicin- [G0383] and tobramycin- [T2503] resistant strains. Amikacin enters the bacterial cell by binding to negatively charged components of the bacterial cell wall disrupting the overall architecture of the cell wall. The mechanism of action is disruption and inhibition of protein synthesis in the target bacteria by binding to the 30S ribosomal subunit.1,2) In addition, amikacin is devoid of any chromophore and/or conjugated system prerequisite for UV and florescent light detection (FLD). Hence, simple and sensitive liquid chromatography methods have been developed for the determination of amikacin.3-5) (The product is for research purpose only.)
References
- (1) The aminoglycosides (a review)
- (2) Amikacin: uses, resistance, and prospects for inhibition (a review)
- (3) Determination of amikacin in body fluid by high-performance liquid-chromatography with chemiluminescence detection
- (4) Development and validation of a novel LC non-derivatization method for the determination of amikacin in pharmaceuticals based on evaporative light scattering detection
- (5) Amikacin sulfate (a review of the profile, physical properties, synthesis, metabolism and pharmacokinetics, stability and methods for determination of amikacin)
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