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| TCI Chemistry News November 2021 | ||||
| TCI offers an extensive catalog of 30,000 high quality organic reagents suitable for benchtop-to-bulk chemistry. This issue covers DualSeal ― airtight-double-cap bottled reagents, Oligonucleotide synthesis reagents, a Hydroxamic acid derivative for selective deacylation reactions, and a Regioselective acylation with MeTAPS-Br. | ||||
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DualSeal ― Airtight-Double-Cap Bottled ReagentsTCI introduced our newly developed double cap system "DualSeal" for moisture/oxygen-sensitive products, allowing you to keep them in good condition until the last drop. We will continuously increase our usage of DualSeal across our product portfolio.Features of DualSeal are as follows; a) Highly airtight double cap structure, b) Air-sensitive reagents can be safely dispensed without exposure to air, c) Even after piercing the septum cap, the PTFE sheet on the blue outer cap provides sealing protection, d) Easy to dispose of caps and bottles separately. | ||||
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Oligonucleotide Synthesis ReagentsOligonucleotide drugs used in clinical applications are generally composed of about 20 nucleotides, but the natural oligonucleotide structure is not suitable for drugs from the perspectives of biostability and affinity to the target. Therefore, chemically modified oligonucleotides are synthesized and utilized as drug candidates. The phosphoramidite method is standard for oligonucleotide synthesis. In this method, one nucleotide addition is conducted by a synthetic cycle using the following three steps: i) coupling of a phosphoramidite and an oligonucleotide at the 5′-OH of the terminal nucleotide with an activator such as 1H-tetrazole and capping of the unreacted hydroxy group; ii) oxidation or sulfurization of the phosphite moiety; and iii) deprotection of the DMT group. This cycle is performed by an automated synthesizer and oligonucleotides can be prepared quickly and easily with this system. | ||||
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Hydroxamic Acid Derivative for Selective Deacylation ReactionsN-Methyl-2-dimethylaminoacetohydroxamic acid [M1316] is known as a reagent for selective deacylations. In a water-including solvent or an alcohol, active esters like aryl esters can be selectively removed by the treatment of M1316 with a substrate. This reaction is applicable to substrates which have both an alkyl ester moiety and an aryl ester moiety, and can selectively remove the acyl groups of aryl ester moiety only. Conventional deacylation reactions require acidic or basic conditions, but this reaction can proceed under a neutral condition at room temperature. | ||||
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Regioselective Acylation with MeTAPS-BrTCI has many articles focused on specific products among our product line, introducing the product characteristics and means of use. The articles featured on asymmetric synthesis using organocatalysts are following:TCI introduces the regioselective acylation of a primary hydroxyl group of 1,2-diol using MeTAPS-Br [H1748] as a catalyst. The reaction report is performed by TCI's synthesis staff. You can see not only the reaction procedure but also comments and analysis of the data from our staff. | ||||
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