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Recently, the guanine quadruplex (G4), a higher-order structure found in sequences containing a sequence of guanines, has been attracting attention. It is estimated that there are more than 370,000 sequences in the human genome that are capable of forming G4. G4 is formed in not only DNA but also RNA. G4 is involved in replication, transcription, translation, and various other biological functions. G4 is also found to be abundant in telomere regions and promoter regions of cancer-related genes. G4 ligands are reported which have planar structure for π-π interaction with G4 and an amino group for interaction at the phosphate moiety.
We have a lineup of representative G4 ligands such as Pyridostatin (Product No. P3244) and Phen-DC3 (Product No. P3182), which show telomerase inhibitory activity and are used as positive controls. BMVC (Product No. B6654) and BMVC2 (Product No. B6675) are also used for G4 detection because their fluorescence intensity increases after coordination.
References
- G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy
- G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions
