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CAS RN: 60-81-1 | Product Number: P0248
Phlorizin
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Purity: >97.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$132.00
|
Contact Us | Contact Us | Contact Us |
|
| 5G |
$363.00
|
Contact Us | Contact Us | 7 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| Product Number | P0248 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__4O__1__0 = 436.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 60-81-1 |
| Related CAS RN | 7061-54-3 |
| Reaxys Registry Number | 66621 |
| PubChem Substance ID | 87574490 |
| SDBS (AIST Spectral DB) | 7601 |
| Merck Index (14) | 7327 |
| MDL Number | MFCD00006591 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | -52.0 to -55.0 deg(C=3.2, EtOH(95%)) |
| Water | max. 8.0 % |
Properties (reference)
| Specific Rotation | -54° (C=3.2,EtOH(95vol%)) |
GHS
Related Laws:
| RTECS# | UC2080000 |
Transport Information:
| HS Number | 2914.50.5000 |
Application
Phlorizin: A Sodium Glucose Co-Transporter Inhibitor (SGLT)
Phlorizin is a 2'-O-glucoside of phloretin [P1966], first isolated from the bark of apple trees. Phlorizin’s principal pharmacological action is to reduce plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of sodium glucose co-transporters (SGLTs). Consequently, phlorizin has been used as a pharmaceutical tool for research of antidiabetic agent.
References
- Phlorizin: a review
- Determination of phenolic acids and flavonoids of apple and pear by high-performance liquid chromatography
- SGLT as a therapeutic target (a review)
- Sodium glucose co-transporter 2 (SGLT2) inhibitors as potential antidiabetic agents (a review)
- Apple Trees to Sodium Glucose Co-Transporter Inhibitors: A Review of SGLT2 Inhibition (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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