Published TCIMAIL newest issue No.197
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CAS RN: 139481-44-0 | Product Number: M3197
Methyl 1-[(2'-Cyano-[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
![Methyl 1-[(2'-Cyano-[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate No-Image](/medias/M3197.jpg?context=bWFzdGVyfHJvb3R8NDg3OTZ8aW1hZ2UvanBlZ3xhR1pqTDJnMVppODRPVEl5TmpJNE5qSXdNekU0TDAwek1UazNMbXB3Wnd8NmE0M2VjZDQyZGJkYTA5N2U5YjY4M2ZmYmZkMWI3NTQwNzY2NmE0NGRiMmVkODJmYzJiYzI4OWNmMDI1YzJhOA)
Purity: >98.0%(HPLC)(N)
Synonyms:
- 1-[(2'-Cyano-[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic Acid Methyl Ester
Product Documents:
Size | Unit Price | Belgium | Japan* | Quantity |
---|---|---|---|---|
25G |
€61.00
|
Contact Us | 5 |
|
100G |
€184.00
|
Contact Us | 20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Product Number | M3197 |
Purity / Analysis Method | >98.0%(HPLC)(N) |
Molecular Formula / Molecular Weight | C__2__5H__2__1N__3O__3 = 411.46 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Air Sensitive |
CAS RN | 139481-44-0 |
Reaxys Registry Number | 6354024 |
PubChem Substance ID | 468592330 |
MDL Number | MFCD09031384 |
Specifications
Appearance | White to Orange to Green powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(with Total Nitrogen) | min. 98.0 % |
Melting point | 166.0 to 170.0 °C |
NMR | confirm to structure |
Properties (reference)
Melting Point | 168 °C |
GHS
Pictogram |
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Signal Word | Warning |
Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
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Application
A Key Synthetic Intermediate of Azilsartan
This product is a key synthetic intermediate of azilsartan [A2601] which is an angiotensin II type 1 (AT1) receptor antagonist used for the treatment of hypertensive.
References
- Synthesis and Angiotensin II Receptor Antagonistic Activities of Benzimidazole Derivatives Bearing Acidic Heterocycles as Novel Tetrazole Bioisosteres
- Improved Process for Azilsartan Medoxomil: A New Angiotensin Receptor Blocker
- Synthesis of azilsartan and its selected potential impurities
- Commercial Synthesis of Azilsartan Kamedoxomil: An Angiotensin II Receptor Blocker
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