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CAS RN: 69123-98-4 | Product Number: D4200
Fialuridine
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Purity: >98.0%(HPLC)
Synonyms:
- 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
- FIAU
- 2'-Fluoro-5-iodoarauracil
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$190.00
|
Contact Us | 1 | 1 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | D4200 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__0FIN__2O__5 = 372.09 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 69123-98-4 |
| Reaxys Registry Number | 892318 |
| PubChem Substance ID | 160871154 |
| Merck Index (14) | 4069 |
| MDL Number | MFCD00866922 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 226 °C |
GHS
Related Laws:
| RTECS# | YQ9512500 |
Transport Information:
| HS Number | 2940.00.6000 |
Application
Fialuridine (FIAU): A Thymidine Nucleoside Analog with Activity against Herpes Viruses and Hepatitis B Virus (HBV)
Fialuridine (FIAU) is a thymidine nucleoside analog with activity against various herpes viruses and hepatitis B virus (HBV). FIAU blocks the action of DNA polymerases, thus inhibiting viral replication. FIAU owes its effect to preferential phosphorylation by virus-encoded thymidine kinase to its 5'-diphosphate form. After further conversion to triphosphate form, it acts as an inhibitor or alternate substrate for the viral DNA polymerase. On the other hand, it appear that FIAU causes mitochondrial toxicity leading to fatal liver failure alongside lactic acidosis. (The product is for research purpose only.)
References
- Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analog for chronic hepatitis B
- Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase
- Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection
- Review article: Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU)
PubMed Literature
Articles/Brochures
TCIMAIL
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Specifications
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