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CAS RN: 85272-31-7 | Product Number: D3135
Di-tert-butylsilyl Bis(trifluoromethanesulfonate)
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Purity: >97.0%(T)
Synonyms:
- Di-tert-butylbis(trifluoromethanesulfonyloxy)silane
- Di-tert-butylsilyl Ditriflate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$45.00
|
2 | 1 | ≥100 |
|
| 5G |
$134.00
|
4 | 1 | ≥100 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D3135 |
| Purity / Analysis Method | >97.0%(T) |
| Molecular Formula / Molecular Weight | C__1__0H__1__8F__6O__6S__2Si = 440.44 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 85272-31-7 |
| Reaxys Registry Number | 3569211 |
| PubChem Substance ID | 87558080 |
Specifications
| Appearance | Colorless to Light orange to Yellow clear liquid |
| Purity(Neutralization titration) | min. 97.0 % |
Properties (reference)
| Flash point | 90 °C |
| Specific Gravity (20/20) | 1.36 |
| Refractive Index | 1.40 |
GHS
| Pictogram |
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| Signal Word | Danger |
| Hazard Statements | H314 : Causes severe skin burns and eye damage. H227 : Combustible liquid. H290 : May be corrosive to metals. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P234 : Keep only in original container. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P390 : Absorb spillage to prevent material damage. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P235 : Store in a well-ventilated place. Keep cool. P406 : Store in corrosive resistant container with a resistant inner liner. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number (DOT-AIR) | UN3265 |
| Class (DOT-AIR) | 8 |
| Packing Group (TCI-A) | II |
| HS Number | 2931.90.9010 |
Application
TCI Practical Example: Protection of a Diol Moiety Using Di-tert-butylsilyl Ditriflate
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Used Chemicals
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Procedure
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Di-tert-butylsilyl ditriflate (0.6 mL, 2.0 mmol) was added dropwise to the solution of uridine (400 mg, 2.0 mmol) and 2,6-lutidine (0.38 mL, 3.3 mmol) in DMF (7 mL) for over 5 minutes at 0 °C. The reaction mixture was stirred for 2 hours at room temperature. Ion exchanged water (20 mL) was added to the reaction mixture, and the aqueous layer was extracted with a mixture of hexane (30 mL) and ethyl acetate (6 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (dichloromethane:methanol = 95:5) to give 1 (501 mg, 79.5% yield) as a white solid.
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Experimenter’s Comments
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The reaction solution was monitored by UPLC.
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Analytical Data
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Compound 1
1H NMR (400 MHz, CDCl3); δ 8.76 (s, 1H), 7.17 (d, J = 8.1 Hz, 1H), 5.69 (d, J = 8.0 Hz,1H), 5.55 (s, 1H), 4.40 (m, 1H), 4.34 (m, 1H), 4.10 (m, 1H), 3.93 (m, 2H), 1.01 (s, 9H), 0.96 (s, 9H).
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Other References
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- A Claisen Approach to 4′-Ed4T
Application
Protection of Diols
References
- E. J. Corey, P. B. Hopkins, Tetrahedron Lett. 1982, 23, 4871.
- V. Serebryany, L. Beigelman, Tetrahedron Lett. 2002, 43, 1983.
- K. Furusawa, Busshitsu Kagaku Kogyo Kenkyusho Hokoku 1994, 2, 337.
- Efficient synthesis of N2-dimethylaminomethylene-2’-O-methylguanosine
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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