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Published TCIMAIL newest issue No.197
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CAS RN: 596-51-0 | Product Number: G0392
Glycopyrrolate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-(2-Cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium Bromide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€124.00
|
5 | 26 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | G0392 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__8BrNO__3 = 398.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| CAS RN | 596-51-0 |
| Reaxys Registry Number | 3642926 |
| PubChem Substance ID | 253660366 |
| Merck Index (14) | 4501 |
| MDL Number | MFCD00072137 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 195 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Alcohol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 209-887-0 |
| RTECS# | UY4337630 |
Transport Information:
| HS Number | 2933998090 |
Application
Glycopyrrolate (NVA237): A Long-Acting Muscarinic Receptor Antagonist (LAMA)
Glycopyrrolate (NVA237) is a synthetic anticholinergic agent and a long-acting muscarinic receptor antagonist (LAMA). It does not cross the blood–brain barrier and consequently has no or few central nervous effects. It has recently been approved as a once-daily treatment for chronic obstructive pulmonary disease (COPD). (The product is for research purpose only.)
References
- Glycopyrrolate: pharmacology and clinical use
- Comparative penetration of glycopyrrolate and atropine across the blood-brain and placental barriers in anesthetized dogs
- Pharmacological characterization of the muscarinic receptor antagonist, glycopyrrolate, in human and guinea pig airways
- Pharmacological assessment of the duration of action of glycopyrrolate vs tiotropium [T3032] and ipratropium in guinea-pig and human airways
- Novel long-acting bronchodilators for COPD and asthma (a review)
- Pharmacology and therapeutics of bronchodilators (a review)
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