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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 300815-41-2 | Product Number: R0267
RS-102895
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1'-[4-(Trifluoromethyl)phenethyl]spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
$137.00
|
17 | 0 | It can be shipped in about 3-4 weeks after ordering |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | R0267 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__1F__3N__2O__2 = 390.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 300815-41-2 |
| Reaxys Registry Number | 15557297 |
| MDL Number | MFCD05865241 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 171.0 to 175.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 173 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
RS-102895: A Selective Chemokine Receptor 2 (CCR2) Antagonist
RS-102895 is a selective chemokine receptor 2 (CCR2) antagonist. CCR2 is a G-protein coupled receptor that is mainly expressed on monocytes, macrophages, and a subset of T cells. There are reported that CCR2 interact with monocyte chemoattractant protein-1 (MCP-1) which stimulates leukocyte chemotaxis to inflammatory sites. (The product is for research purpose only.)
References
- Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle
- Chemokine receptor 2b inhibition provides renal protection in angiotensin II-salt
- Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis
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