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CAS RN: 113-52-0 | Product Number: I0971
Imipramine Hydrochloride
Purity: >98.0%(HPLC)
Synonyms:
- 10,11-Dihydro-N,N-dimethyl-5H-dibenzo[b,f]azepine-5-propanamine Hydrochloride
- 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[b,f]azepine Hydrochloride
Product Documents:
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Product Number | I0971 |
Purity / Analysis Method | >98.0%(HPLC) |
Molecular Formula / Molecular Weight | C__1__9H__2__4N__2·HCl = 316.87 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Condition to Avoid | Light Sensitive |
Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
CAS RN | 113-52-0 |
Related CAS RN | 50-49-7 |
Reaxys Registry Number | 3576963 |
PubChem Substance ID | 253661339 |
Merck Index (14) | 4920 |
MDL Number | MFCD00012669 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 97.0 % |
Melting point | 171.0 to 175.0 °C |
Properties (reference)
Melting Point | 173 °C |
Maximum Absorption Wavelength | 260 nm |
GHS
Pictogram | |
Signal Word | Warning |
Hazard Statements | H302 : Harmful if swallowed. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
RTECS# | HO1925000 |
Transport Information:
H.S.code* | 2933.99-000 |
Application
Imipramine hydrochloride: An Inhibitor of Serotonin or Noradrenaline Re-Uptake Transporters
Imipramine hydrochloride is the first tricyclic antidepressant agent synthesized in 1948. Imipramine works as an inhibitor of serotonin (5-hydroxytryptamine, 5HT [S0370]) or L-noradrenaline [A0906] re-uptake transporters in brain neurons, but it also inhibits the release of acetylcholine from nerves. (The product is for research purpose only.)
References
- Inhibition of the uptake of tritiated catechol amines by antidepressant and related agents
- "Behavioral despair" in rats and mice: strain differences and the effects of imipramine
- Imipramine hydrochloride (a review)
- Transdermal drug delivery of imipramine hydrochloride. I. Effect of terpenes
- Depression and antidepressants: Insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters (a review)
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