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CAS RN: 29342-05-0 | Product Number: C3483
Ciclopirox
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
- 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$32.00
|
9 | 2 | Contact Us | |
| 5G |
$109.00
|
7 | 0 | Contact Us |
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| Product Number | C3483 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__7NO__2 = 207.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 29342-05-0 |
| Reaxys Registry Number | 1533423 |
| MDL Number | MFCD00599441 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 142.0 to 146.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 144 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | UU7785200 |
Transport Information:
| H.S.code* | 2933.79-000 |
Application
Ciclopirox: An Antifungal Agent with Additional Antibacterial, Anti-Inflammatory and Antitumor Activities
Ciclopirox is a synthetic, broad-spectrum antifungal agent with additional antibacterial, anti-inflammatory and also recently antitumor activities. In vitro studies have suggested that ciclopirox acts by chelation of trivalent cations, such as Fe3+ and Al3+, resulting in the inhibition of the metal-dependent enzymes that are responsible for the cellular metabolism, organization of cell wall structure and other crucial cell functions.1,2) In addition, ciclopirox exerts its anti-inflammatory activity by scavenging the reactive oxygen species (ROS) released from inflammatory cells.2) In 2000s, some studies have reported that ciclopirox olamine [C3545] could be repositioned as a new antitumor agent.3-5) (The product is for research purpose only.)
References
- 1) Ciclopirox: an overview
- 2) Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent (a review)
- 3) Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells
- 4) The antitumor activity of the fungicide ciclopirox
- 5) The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy (a review)
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