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CAS RN: 69712-56-7 | Product Number: C2936
Cefotetan
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
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| 250MG |
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Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | C2936 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__7N__7O__8S__4 = 575.60 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 69712-56-7 |
| Reaxys Registry Number | 5697364 |
| PubChem Substance ID | 253662091 |
| Merck Index (14) | 1934 |
| MDL Number | MFCD00864983 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | +115.0 to +122.0 deg(C=1,0.5%NaHCO3 sol.(0.5%)) |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | 118° (C=1,0.5% NaHCO3) |
| Solubility (slightly sol. in) | Methanol |
GHS
Related Laws:
| RTECS# | XI0330800 |
Transport Information:
| H.S.code* | 2941.90-000 |
Application
Cefotetan: A (7S)-Methoxy Cephalosporin (Cephamycin)
Cefotetan, a (7S)-methoxy cephalosporin (cephamycin), is chemically synthesized form 7-MAC [M2129]. The steric hindrance effect that is enhanced by introducing (7S)-methoxy into the β-lactam ring significantly increases the stability of β-lactam antibiotics against β-lactamases, and to some extent reduces the problems of bacterial drug-resistance. Cefotetan has a broad spectrum of activity against Gram-negative and Gram-positive bacteria, and is generally more active against Gram-negative bacteria than the ‘first and second generation’ cephalosporins. Cefotetan is particularly active against Enterobacter but has little activity against Pseudomonas aeruginosa.
References
- Cefotetan. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use
- Cefotetan: a review of the microbiologic properties and antimicrobial spectrum
- A simple and sensitive liquid chromatographic technique for the determination of cefotetan disodium in human plasma and its application in a pharmacokinetic study
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