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ROCK Inhibitor

No.190(August 2022)
Y0018
Y 27632 Dihydrochloride (1)
(*This product is discontinued.)

ROCK Inhibitor

Y 27632 is a cell-permeable and selective inhibitor of Rho-associated, coiled-coil-containing protein kinase (ROCK) and 1 is its dihydrochloride. Y 27632 inhibits ROCK1 (Ki = 220 nM) and ROCK2 (Ki = 300 nM). The inhibition manner of the enzymes by Y 27632 is competitive with ATP for binding to the catalytic site.1,2) Y 27632 also prevents dissociation-induced apoptosis (anoikis) of human embryonic stem (ES) cells, when they are dissociated to single cells. Therefore, cloning efficiency of human ES cells is increased by the use of Y 27632.3)

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