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CAS RN: 24003-58-5 | Product Number: Q0118
QX 314 Bromide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-(2,6-Dimethylanilino)-N,N,N-triethyl-2-oxoethanaminium Bromide
- 2-[(2,6-Dimethylphenyl)amino]-N,N,N-triethyl-2-oxoethan-1-aminium Bromide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$102.00
|
Contact Us | Contact Us | 24 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | Q0118 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__7BrN__2O = 343.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 24003-58-5 |
| Reaxys Registry Number | 3789225 |
| MDL Number | MFCD00083182 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Precipitation Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 215 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2924.29.6250 |
Application
QX 314 Bromide: A Membrane-Impermeable Sodium Channel Blocker
QX 314 bromide is a membrane-impermeable lidocaine [L0156] derivative and sodium channel blocker. QX 314 bromide has been reported to selectively block sodium channels on nociceptive neurons when delivered intracellularly through the pore of the noxious heat-sensitive TRPV1 (transient receptor potential vanilloid subfamily member 1) channel, but is ineffective when applied extracellularly.1) In addition, the combination of lidocaine (as a TRPV1 agonist) and QX-314 in an injectable formulation may be a useful adjunct for regional pain control.2,3) (The product is for research use only.)
References
- 1) Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
- 2) The quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivo
- 3) Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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