Make sure to sign up for an account today for exclusive coupons and free ground shipping on orders over $75!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 155148-31-5 | Product Number: P2620
AMD-3100 Octahydrochloride
×
![]()
×
Purity: >98.0%(HPLC)
Synonyms:
- Plerixafor Octahydrochloride
- JM-3100
- SID-791
- 1,4-Bis[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]benzene Octahydrochloride
- 1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane Octahydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25MG |
$165.00
|
1 | 1 | 6 |
|
| 100MG |
$498.00
|
Contact Us | 1 | 16 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | P2620 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__5__4N__8·8HCl = 794.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 155148-31-5 |
| Reaxys Registry Number | 8182245 |
| PubChem Substance ID | 468592637 |
| MDL Number | MFCD04974488 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Precipitation Titration) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 245 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
| RTECS# | XA5255300 |
Transport Information:
| HS Number | 2933.99.9701 |
Application
AMD-3100 Octahydrochloride: A CXC Chemokine Receptor Type 4 (CXCR4) Antagonist
AMD-3100 octahydrochloride (plerixafor octahydrochloride) is an antagonist of CXC chemokine receptor type 4 (CXCR4), which is a chemokine receptor expressed on immune cells and cancer cells. CXCR4 antagonists, including AMD-3100, were initially developed for the treatment of HIV-1 (AIDS), where CXCR4 functions as a co-receptor for virus entry into T cells.1) Subsequently, CXCR4 antagonists were noticed to induce leukocytosis, and are currently used for mobilization of hematopoietic stem cells.2,3) Recently, it has been reported that CXCR4 induces migration of cancer cells and is important for processes such as metastasis.3,4) Therefore, CXCR4 antagonists are expected to regulate these tumor metastatic processes. (The product is for research purpose only.)
References
- 1) AMD3100, a small molecule inhibitor of HIV-1 entry via the CXC4 co-receptor
- 2) Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
- 3) CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers (a review)
- 4) CXCR4 in breast cancer: oncogenic role and therapeutic targeting
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.