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CAS RN: 14222-60-7 | Product Number: P2302
Prothionamide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Propylpyridine-4-carbothioamide
- 2-Propylthioisonicotinamide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$47.00
|
4 | 2 | ≥40 |
|
| 25G |
$152.00
|
Contact Us | Contact Us | 20 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | P2302 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2S = 180.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 14222-60-7 |
| Reaxys Registry Number | 118164 |
| PubChem Substance ID | 253660961 |
| Merck Index (14) | 7891 |
| MDL Number | MFCD00464119 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 141.0 to 145.0 °C |
Properties (reference)
| Melting Point | 143 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NS0650000 |
Transport Information:
| HS Number | 2933.39.9200 |
Application
Prothionamide: A Thioamide Anti-Tuberculosis Agent
Prothionamide and ethionamide [E0695] are thioamide anti-tuberculosis agents. They have activity against Mycobacterium tuberculosis, Mycobacterium leprae murium and Mycobacterium avium. The precise mechanisms of action remain unknown, but it has been reported that the thioamides are prodrugs that are oxidatively converted to their active forms by the flavin monooxygenase EtaA of Mycobacterium tuberculosis.
References
- Mechanism of thioamide drug action against tuberculosis and leprosy
- Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases (a review)
- High-performance liquid chromatographic determination of ethionamide and prothionamide in body fluids
PubMed Literature
Articles/Brochures
TCIMAIL
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Specifications
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