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CAS RN: 33069-62-4 | Product Number: P1632
Paclitaxel
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$325.00
|
1 | Contact Us | ≥100 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | P1632 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__7H__5__1NO__1__4 = 853.92 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 33069-62-4 |
| Reaxys Registry Number | 4290260 |
| PubChem Substance ID | 87558555 |
| MDL Number | MFCD00869953 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | -49.0 to -54.0 deg(C=1, MeOH) |
Properties (reference)
| Melting Point | 216 °C |
| Specific Rotation | -52° (C=1,MeOH) |
| Maximum Absorption Wavelength | 227(MeOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P285 : In case of inadequate ventilation wear respiratory protection. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P272 : Contaminated work clothing must not be allowed out of the workplace. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P405 : Store locked up. |
Related Laws:
| RTECS# | DA8340750 |
Transport Information:
| HS Number | 2914.50.3000 |
Application
Paraptosis research
Reference
- Taxol Induces Paraptosis Independent of Both Protein Synthesis and MAPK Pathway
- Taxol and taxotere: discovery, chemistry, and structure-activity relationships
- Microtubules as a target for anticancer drugs
- Paclitaxel-induced cell death: where the cell cycle and apoptosis come together
- Mechanism of action of antitumor drugs that interact with microtubules and tubulin
- A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel
- R. C. Polomano, A. J. Mannes, U. S. Clark, G. J. Bennett, Pain 2001, 94, 293.
- Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
- Cremophor EL the drawbacks and advantages of vehicle selection for drug formulation
- Paclitaxel and its formulations
- Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
Application
Paclitaxel: An Antimicrotubule Agent
Paclitaxel is an antimicrotubule agent. It was initially extracted from the bark of Taxus brevifolia, and at present, it is semi-synthesized from 10-deacetylbaccatin III [D4148] isolated from the yew tree (Genera Taxus). The tubulin has two subunits, α and β, which are arranged in a cylindrical pattern to form a hollow protein. Paclitaxel specifically binds to the β-tubulin subunit of microtubules, promotes and stabilizes microtubule polymerization. As the result, it influences the formation and function of spindles (made up of microtubules) during mitosis (M phase), and also affects the function of microtubules in the cell. It is thought to be cytotoxic by arresting the cell cycle during M phase. For your reference, [B4127] and [H1656] are synthetic Intermediates of the side chains of docetaxel [D4102] and paclitaxel. (The product is for research purpose only.)
References
Application
Reagent for pain model
References
Application
Reviews on Formulations and Drug Delivery Systems (DDS) of Paclitaxel
References
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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