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CAS RN: 94-62-2 | Product Number: P0460
Piperine
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Purity: >97.0%(HPLC)(N)
Synonyms:
- 1-[5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoyl]piperidine
- 1-Piperoylpiperidine
- 1-Piperylpiperidine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$21.00
|
Contact Us | 2 | ≥80 |
|
| 5G |
$56.00
|
Contact Us | 2 | ≥40 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | P0460 |
| Purity / Analysis Method | >97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__7H__1__9NO__3 = 285.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 94-62-2 |
| Reaxys Registry Number | 90741 |
| PubChem Substance ID | 87574654 |
| SDBS (AIST Spectral DB) | 11113 |
| Merck Index (14) | 7472 |
| MDL Number | MFCD00005839 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 128.0 to 133.0 °C |
Properties (reference)
| Melting Point | 129 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | TN2321500 |
Transport Information:
| HS Number | 2934.99.4400 |
Application
Efflux pump research / Efflux pump inhibitor
References
- Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus
- Piperine as an inhibitor of Rv1258c, a putative multidrug efflux pump of Mycobacterium tuberculosis
Application
Piperine: A Natural Piperidine Alkaloid with TRPV1 Activation Ability
Piperine is a natural piperidine alkaloid responsible for the pungency of black pepper. It has been used as a traditional medicine for the treatment of various diseases. The pungency results from activation of the heat- and acidity-sensing TRPV1 ion channels, also known as the capsaicin receptor.1,2) In addition, piperine inhibits P-glycoprotein and/or CYP3A4 which are responsible for the metabolism and transport of xenobiotics and metabolites in the body.3,4) Therefore, piperine has potential to increase bioavailability of other compounds in food and dietary supplements, such as curcumin [C0434][C2302].4,5) (The product is for research purpose only.)
References
- 1) Black pepper and its pungent principle-piperine: A review of diverse physiological effects (a review)
- 2) Piperine: researchers discover new flavor in an ancient spice (a review)
- 3) Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4
- 4) Piper nigrum and Piperine: An Update (a review)
- 5) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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Analytical Charts
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