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CAS RN: 70458-96-7 | Product Number: N0817
Norfloxacin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$54.00
|
3 | 2 | ≥60 |
|
| 25G |
$135.00
|
6 | 1 | 32 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | N0817 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__8FN__3O__3 = 319.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 70458-96-7 |
| Reaxys Registry Number | 567897 |
| PubChem Substance ID | 125307523 |
| SDBS (AIST Spectral DB) | 52829 |
| Merck Index (14) | 6700 |
| MDL Number | MFCD00079532 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 221 °C |
GHS
Related Laws:
| RTECS# | VB2005000 |
Transport Information:
| HS Number | 2941.90.5000 |
Application
初のフルオロキノロン系合成抗菌剤，ノルフロキサシン
Norfloxacin is the first fluoroquinolone antibacterial reagent which is synthesized from [C2897] with piperazine. Its structure is related to nalidixic acid [N0490] but its potency has been increased by a fluorine atom and by a piperazine moeity. Thereby, norfloxacin has a broad spectrum of activity against both Gram-positive bacteria and Gram-negative bacteria. Norfloxacin and the other fluoroquinolones inhibit bacterial DNA synthesis by inhibiting the enzyme gyrase which catalyzes the operations of the DNA double strand such as opening, under winding, and closing. Fluoroquinolones appear to prevent specifically the resealing of opened DNA strands and thereby act bactericidally.
References
- Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids
- Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model
- Norfloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use
- Norfloxacin (a review of synthesis and physical properties of norfloxacin)
- Quinolone-mediated bacterial death (a review)
- Analysis of fluoroquinolones in biological fluids by high-performance liquid chromatography (a review)
PubMed Literature
Articles/Brochures
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