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CAS RN: 24807-55-4 | Product Number: N0477
3-Nitro-1,2,4-triazole [Coupling Agent]
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![3-Nitro-1,2,4-triazole [Coupling Agent]](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "3-Nitro-1,2,4-triazole [Coupling Agent]")
Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$16.00
|
1 | 4 | 1 |
|
| 5G |
$34.00
|
3 | 1 | ≥40 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | N0477 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2H__2N__4O__2 = 114.06 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 24807-55-4 |
| Reaxys Registry Number | 607167 |
| PubChem Substance ID | 87573806 |
| SDBS (AIST Spectral DB) | 23862 |
| MDL Number | MFCD00009749 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 214 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| HS Number | 2933.99.9701 |
Application
A Condensing Agent
Experimental procedure: to a solution of N-Boc-Val-OH (160 mg, 0.74 mmol) and Et3N (140 µ L, 1.0 mmol) in THF is added 1 (395 mg, 0.44 mmol). The mixture is concentrated, coevaporated with pyridine and then with toluene, and redissolved in THF (4 mL). DIPEA (0.38 mL, 2.2 mmol), BOP-Cl (0.28 g, 1.1 mmol), and 3-nitro-1,2,4-triazole (0.13 g, 1.1 mmol) were added successively. The reaction mixture is stirred at rt for 1 h. Chromatography on silica gel with 0.5% Et3N and 20 － 100% EtOAc in hexanes gives 2 (0.39 g, 81% yield).
References
- Discovery of 4’-Chloromethyl-2’-deoxy-3’,5’-di‑O ‑isobutyryl-2’-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection
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