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CAS RN: 2140-77-4 | Product Number: M3745
N2-Methylguanosine
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-(methylamino)-1,9-dihydro-6H-purin-6-one
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$150.00
|
Contact Us | Contact Us | 26 |
|
| 50MG |
$351.00
|
Contact Us | Contact Us | 33 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | M3745 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__1H__1__5N__5O__5 = 297.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 2140-77-4 |
| Reaxys Registry Number | 46491 |
| MDL Number | MFCD00057039 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 233 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934.99.9001 |
Application
N2-Methylguanosine: A Modified Nucleoside Found in the tRNA of Nearly All Archaea and Eukaryotes
N2-Methylguanosine (m2G) is a modified nucleoside found in the tRNA of nearly all archaea and eukaryotes but not in bacteria. It plays crucial roles in the control and stabilization of tRNA.1-3) In addition, it has been reported that some modified nucleosides, including N2-methylguanosine, are excreted in abnormal amounts in the urine of patients with malignancies. Thus, the modified nucleosides may be useful tumor markers.4,5)
References
- 1) Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA
- 2) Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14
- 3) iRNA-m7G: Identifying N7-methylguanosine Sites by Fusing Multiple Features
- 4) Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control
- 5) Liquid chromatography tandem mass spectrometry study of urinary nucleosides as potential cancer markers
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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