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CAS RN: 578-76-7 | Product Number: M3490
7-Methylguanine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Amino-7-methyl-3,7-dihydro-6H-purin-6-one
- 2-Amino-7-methyl-1H-purin-6(7H)-one
- 2-Amino-6-hydroxy-7-methylpurine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 250MG |
$186.00
|
Contact Us | Contact Us | 20 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | M3490 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__7N__5O = 165.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 578-76-7 |
| Reaxys Registry Number | 20706740 |
| MDL Number | MFCD00038003 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
| RTECS# | MF8464000 |
Transport Information:
| HS Number | 2933.99.9701 |
Application
7-Methylguanine: A Metabolite of DNA Methylation
7-Methylguanine (m7Gua) is a metabolite of DNA methylation. There are reports that it has been used as a biomarker for DNA methylation which is one of the most common and most studied epigenetic processes.1-3) For your reference, the 7-methylguanine ribonucleoside is called 7-methylguanosine [M3465]. However, the 7-methylguanine base is not involved in the synthesis of nucleotides and not incorporated directly into nucleic acids.4) (The product is for research purpose only.)
References
- 1) Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosine
- 2) Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: effect modification by mu class glutathione-S-transferases
- 3) Rapid and sensitive quantification of urinary N7-methylguanine by isotope-dilution liquid chromatography/electrospray ionization tandem mass spectrometry with on-line solid-phase extraction
- 4) O6-methylguanine, but not N7-methylguanine or N3-methyladenine, induces gene mutations, sister-chromatid exchanges and chromosomal aberrations in Chinese hamster cells
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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