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CAS RN: 362-07-2 | Product Number: M2530
2-Methoxy-β-estradiol
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Purity: >97.0%(GC)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25MG |
$40.00
|
1 | 2 | 28 |
|
| 100MG |
$106.00
|
1 | Contact Us | 25 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | M2530 |
| Purity / Analysis Method | >97.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__6O__3 = 302.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 362-07-2 |
| Reaxys Registry Number | 3147966 |
| PubChem Substance ID | 253661672 |
| MDL Number | MFCD00010489 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 97.0 % |
| Melting point | 186.0 to 190.0 °C |
| Specific rotation [a]20/D | +105 to + 110 deg(C=0.5, THF) |
Properties (reference)
| Melting Point | 187 °C |
| Specific Rotation | 107° (C=0.5,THF) |
| Maximum Absorption Wavelength | 286(EtOH) nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | KG7537500 |
Transport Information:
| HS Number | 2937.23.5050 |
Application
Hypoxia inducible factor (HIF) research / Hypoxia inducible factor (HIF) inhibitor
Reference
- Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation
Application
2-Methoxy-β-estradiol (abbrev: 2ME2): A Natural Metabolite of β-Estradiol [E0025] with Antiangiogenic and Antitumor Activities
2-Methoxy-β-estradiol (abbrev: 2ME2) is a natural metabolite of β-estradiol [E0025] with antiangiogenic and antitumor activities. 2Me2, once considered an inactive end metabolite, has recently gained more and more interest due to its marked antiangiogenic and antitumor properties in numerous animal and experimental investigations.
References
- The endogenous estrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumor growth
- Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol
- 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
- 2-Methoxyestradiol - a unique blend of activities generating a new class of anti-tumor/anti-inflammatory agents (a review)
- Potential vascular actions of 2-methoxyestradiol (a review)
- 2-Methoxyestradiol-Biology and mechanism of action (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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