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CAS RN: 100986-89-8 | Product Number: L0238
Levofloxacin Q-Acid
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$61.00
|
4 | 1 | ≥40 |
|
| 5G |
$184.00
|
2 | 1 | 26 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | L0238 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__9F__2NO__4 = 281.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 100986-89-8 |
| Reaxys Registry Number | 5764829 |
| PubChem Substance ID | 160871226 |
| MDL Number | MFCD04039905 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -62.0 to -66.0 deg(C=1、DMSO) |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | -64° (C=1,DMSO) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| HS Number | 2934.99.9001 |
Application
A Key Synthetic Intermediate of Levofloxacin and its Fluoromethyl Derivatives
This product is a key synthetic intermediate of levofloxacin [L0193] (optically active ofloxacin [O0403]) and its fluoromethyl derivativea which are fluoroquinolone antibiotics.
文献
- Synthesis and antibacterial activities of optically active ofloxacin
- Synthesis and antibacterial activities of optically active ofloxacin and its fluoromethyl derivative
- Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl- 10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin)
- A validated stability-indicating RP-HPLC method for levofloxacin in the presence of degradation products, its process related impurities and identification of oxidative degradant
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